Efung News | Real Biotechnology's Non-Camptothecin Toxin Debuts at CBI 2026, Breaking Through the ADC Drug Resistance Bottleneck
Recently, the CBI 2026 Biomedical Innovation Expo concluded in Suzhou, with an exhibition area of over 36,000 square meters and more than 20,000 participants gathered on site to jointly create a new industry ecosystem. The conference featured multiple parallel forums. At the ADC New Drug Discovery and Front-End Technology Innovation Forum, Dr. Dang Qun, President of Real Biotechnology, shared the companys latest achievements in overcoming ADC drug resistance with its novel non-camptothecin TOPO1 inhibitor platform.ImagePrecision therapeutic approaches represented by next-generation ADC drugs are reshaping the landscape of tumor treatment, among which TOPO1 inhibitor payloads are the most widely used clinically. However, with the widespread use of such drugs, issues of TOPO1 toxin-related target mutations and efflux pump resistance have become increasingly prominent, with cross-resistance emerging among different antibody ADCs, becoming a key bottleneck constraining efficacy improvement...
2026
-
09
-
10